Phenotypic characterization of endometrial stromal sarcoma of the uterus

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Phenotypic characterization of endometrial stromal sarcoma of the uterus.

Endometrial stromal sarcoma (ESS) of the uterus is a rare uterine malignancy that has not been characterized in detail. To characterize the phenotype of ESS of the uterus, we extracted RNA from ESS and the stroma of normal endometrium using a tissue microdissection system and compared the expression profiles in the two tissues. After suppression subtractive hybridization and differential screen...

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Genomic landscape of endometrial stromal sarcoma of uterus.

Although recurrent gene fusions such as JAZF1-JJAZ1 are considered driver events for endometrial stromal sarcoma (ESS) development, other genomic alterations remain largely unknown. In this study, we performed whole-exome sequencing, transcriptome sequencing and copy number profiling for five ESSs (three low-grade ESS (LG-ESS) and two undifferentiated uterine sarcomas (UUSs)). All three LG-ESSs...

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Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases.

BACKGROUND Low-grade endometrial sarcoma is a rare gynecological tumor (0.2% of female genital tract tumors) mainly observed in women before their 50's. PATIENTS AND METHODS The authors present a series of 10 patients followed in two institutions and describe the treatment administered (cytoreductive surgery, i.e. bilateral annexectomy and total hysterectomy, and medical treatments) and the f...

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Myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Case report.

We report the case of a 73-year-old female with myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Grossly, the tumor sized 130 x 130 x 100 mm involved the uterine corpus almost in its entirety. Histologically, the tumor consisted of two cell types. In some areas, the tumor cells showed typical features of endometrial stromal tumors and resembled stromal c...

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Endometrial stromal sarcoma with endometrioid adenocarcinoma of the uterus: a case report.

Endometrial stromal sarcoma (ESS) is a rare malignant neoplasm of the uterus. We report the first case of undifferentiated ESS (UES) coexistent with grade 1 endometrioid adenocarcinoma in a 73-year-old female who presented with irregular vaginal bleeding for 4 days after menopause 20 years. Imaging examination including Magnetic Resonance Imaging (MRI) demonstrated multi-node reflection in uter...

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ژورنال

عنوان ژورنال: Cancer Science

سال: 2006

ISSN: 1347-9032,1349-7006

DOI: 10.1111/j.1349-7006.2006.00147.x